Dexmedetomidine hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

α2-肾上腺素能受体激动剂，因其镇痛和镇静特性而用于兽医学。

An agonist of α2-adrenergic receptor that used in veterinary medicine for its analgesic and sedative properties; also protects against lung injury induced by ischemia-reperfusion through inhibition of autophagy in rats.(In Vitro):Medetomidine has high selectivity for α2 adrenoceptors (Ki=1.08 nM) over α1 adrenoceptors (Ki=1750 nM) in rat brain membranes as measured by the displacement of [3H]clonidine.Medetomidine (0.1-100 nM) inhibits the twitch response in field-stimulated mouse vas deferens, with a pD2 of 9.0.(In Vivo):Medetomidine (10-100 μg/kg; i.v. at 5-min intervals) produces a dose-dependent pupillary dilatation in pentobarbitone-anaesthetized rats.

Medetomidine has high selectivity for α2 adrenoceptors (Ki=1.08 nM) over α1 adrenoceptors (Ki=1750 nM) in rat brain membranes as measured by the displacement of [3H]clonidine.Medetomidine (0.1-100 nM) inhibits the twitch response in field-stimulated mouse vas deferens, with a pD2 of 9.0.

Medetomidine (10-100 μg/kg; i.v. at 5-min intervals) produces a dose-dependent pupillary dilatation in pentobarbitone-anaesthetized rats. Animal Model:Female Sprague-Dawley rats (270-350 g)Dosage:1, 5, 10, 50, 100 mg/kg Administration:I.v. at 5-min intervals Result:Produced the pupil dilatation of 2.5 mm (approximately half of the maximum effect) at the cumulative dose of 4 μg/kg.

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Angiogenesis

Adrenergic Receptor

α2-adrenoceptor

Neurological Disease

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145108-58-3

236.7405

C13H17ClN2

>98% (HPLC)

10 mM in DMSO

CC1=C(C)C([C@H](C)C2=CN=CN2)=CC=C1.Cl

1H-Imidazole, 5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-, hydrochloride (1:1)

(-20℃)

With Ice Pack

≥ 2 years